Highly Stable Near-Infrared Fluorescent Organic Nanoparticles with a Large Stokes Shift for Noninvasive Long-Term Cellular Imaging.
Identifieur interne : 000190 ( Main/Exploration ); précédent : 000189; suivant : 000191Highly Stable Near-Infrared Fluorescent Organic Nanoparticles with a Large Stokes Shift for Noninvasive Long-Term Cellular Imaging.
Auteurs : Jinfeng Zhang [République populaire de Chine] ; Rui Chen [République populaire de Chine] ; Zelin Zhu [République populaire de Chine] ; Chihaya Adachi [Japon] ; Xiaohong Zhang [République populaire de Chine] ; Chun-Sing Lee [République populaire de Chine]Source :
- ACS applied materials & interfaces ; 2015.
Abstract
Fluorescent organic nanoparticles based on small molecules have been regarded as promising candidates for bioimaging in recent years. In this study, we report a highly stable near-infrared (NIR) fluorescent organic nanoprobes based on nanoparticles of an anthraquinone derivate with strong aggregation-induced emission (AIE) characteristics and a large Stokes shift (>175 nm). These endow the nanoprobe with high fluorescent brightness and high signal-to-noise ratio. On the other hand, the nanoprobe also shows low cytotoxicity, good stability over a wide pH range, superior resistance against photodegradation and photobleaching comparing to typical commercial fluorescent organic dyes such as fluorescein sodium. Endowed with such merits in term of optical performance, biocompatibility, and stability, the nanoprobe is demonstrated to be an ideal fluorescent probe for noninvasive long-term cellular tracing and imaging applications. As an example, it is shown that strong red fluorescence from the nanoprobe can still be clearly observed in A549 human lung cancer cells after incubation for six generations over 15 days.
DOI: 10.1021/acsami.5b08539
PubMed: 26558487
Affiliations:
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China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Center of Super-Diamond and Advanced Films (COSDAF) & Department of Physics and Materials Science, City University of Hong Kong , 83 Tat Chee Avenue, Kowloon, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Rui" sort="Chen, Rui" uniqKey="Chen R" first="Rui" last="Chen">Rui Chen</name><affiliation wicri:level="1"><nlm:affiliation>Center of Super-Diamond and Advanced Films (COSDAF) & Department of Physics and Materials Science, City University of Hong Kong , 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, P. R. 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China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Center of Super-Diamond and Advanced Films (COSDAF) & Department of Physics and Materials Science, City University of Hong Kong , 83 Tat Chee Avenue, Kowloon, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26558487</idno><idno type="pmid">26558487</idno><idno type="doi">10.1021/acsami.5b08539</idno><idno type="wicri:Area/PubMed/Corpus">000039</idno><idno type="wicri:Area/PubMed/Curation">000039</idno><idno type="wicri:Area/PubMed/Checkpoint">000093</idno><idno type="wicri:Area/Ncbi/Merge">000E35</idno><idno type="wicri:Area/Ncbi/Curation">000E35</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E35</idno><idno type="wicri:Area/Main/Merge">000187</idno><idno type="wicri:Area/Main/Curation">000190</idno><idno type="wicri:Area/Main/Exploration">000190</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Highly Stable Near-Infrared Fluorescent Organic Nanoparticles with a Large Stokes Shift for Noninvasive Long-Term Cellular Imaging.</title><author><name sortKey="Zhang, Jinfeng" sort="Zhang, Jinfeng" uniqKey="Zhang J" first="Jinfeng" last="Zhang">Jinfeng Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Center of Super-Diamond and Advanced Films (COSDAF) & Department of Physics and Materials Science, City University of Hong Kong , 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Center of Super-Diamond and Advanced Films (COSDAF) & Department of Physics and Materials Science, City University of Hong Kong , 83 Tat Chee Avenue, Kowloon, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Rui" sort="Chen, Rui" uniqKey="Chen R" first="Rui" last="Chen">Rui Chen</name><affiliation wicri:level="1"><nlm:affiliation>Center of Super-Diamond and Advanced Films (COSDAF) & Department of Physics and Materials Science, City University of Hong Kong , 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Center of Super-Diamond and Advanced Films (COSDAF) & Department of Physics and Materials Science, City University of Hong Kong , 83 Tat Chee Avenue, Kowloon, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Zelin" sort="Zhu, Zelin" uniqKey="Zhu Z" first="Zelin" last="Zhu">Zelin Zhu</name><affiliation wicri:level="1"><nlm:affiliation>Center of Super-Diamond and Advanced Films (COSDAF) & Department of Physics and Materials Science, City University of Hong Kong , 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Center of Super-Diamond and Advanced Films (COSDAF) & Department of Physics and Materials Science, City University of Hong Kong , 83 Tat Chee Avenue, Kowloon, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Adachi, Chihaya" sort="Adachi, Chihaya" uniqKey="Adachi C" first="Chihaya" last="Adachi">Chihaya Adachi</name><affiliation wicri:level="1"><nlm:affiliation>Center for Organic Photonics and Electronics Research (OPERA), Kyushu University , 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Center for Organic Photonics and Electronics Research (OPERA), Kyushu University , 744 Motooka, Nishi-ku, Fukuoka 819-0395</wicri:regionArea><wicri:noRegion>Fukuoka 819-0395</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Xiaohong" sort="Zhang, Xiaohong" uniqKey="Zhang X" first="Xiaohong" last="Zhang">Xiaohong Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Functional Nano & Soft Materials Laboratory (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University , Suzhou, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Functional Nano & Soft Materials Laboratory (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University , Suzhou</wicri:regionArea><wicri:noRegion>Suzhou</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Chun Sing" sort="Lee, Chun Sing" uniqKey="Lee C" first="Chun-Sing" last="Lee">Chun-Sing Lee</name><affiliation wicri:level="1"><nlm:affiliation>Center of Super-Diamond and Advanced Films (COSDAF) & Department of Physics and Materials Science, City University of Hong Kong , 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Center of Super-Diamond and Advanced Films (COSDAF) & Department of Physics and Materials Science, City University of Hong Kong , 83 Tat Chee Avenue, Kowloon, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author></analytic><series><title level="j">ACS applied materials & interfaces</title><idno type="e-ISSN">1944-8252</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fluorescent organic nanoparticles based on small molecules have been regarded as promising candidates for bioimaging in recent years. In this study, we report a highly stable near-infrared (NIR) fluorescent organic nanoprobes based on nanoparticles of an anthraquinone derivate with strong aggregation-induced emission (AIE) characteristics and a large Stokes shift (>175 nm). These endow the nanoprobe with high fluorescent brightness and high signal-to-noise ratio. On the other hand, the nanoprobe also shows low cytotoxicity, good stability over a wide pH range, superior resistance against photodegradation and photobleaching comparing to typical commercial fluorescent organic dyes such as fluorescein sodium. Endowed with such merits in term of optical performance, biocompatibility, and stability, the nanoprobe is demonstrated to be an ideal fluorescent probe for noninvasive long-term cellular tracing and imaging applications. As an example, it is shown that strong red fluorescence from the nanoprobe can still be clearly observed in A549 human lung cancer cells after incubation for six generations over 15 days.</div></front></TEI><affiliations><list><country><li>Japon</li><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Jinfeng" sort="Zhang, Jinfeng" uniqKey="Zhang J" first="Jinfeng" last="Zhang">Jinfeng Zhang</name></noRegion><name sortKey="Chen, Rui" sort="Chen, Rui" uniqKey="Chen R" first="Rui" last="Chen">Rui Chen</name><name sortKey="Lee, Chun Sing" sort="Lee, Chun Sing" uniqKey="Lee C" first="Chun-Sing" last="Lee">Chun-Sing Lee</name><name sortKey="Zhang, Xiaohong" sort="Zhang, Xiaohong" uniqKey="Zhang X" first="Xiaohong" last="Zhang">Xiaohong Zhang</name><name sortKey="Zhu, Zelin" sort="Zhu, Zelin" uniqKey="Zhu Z" first="Zelin" last="Zhu">Zelin Zhu</name></country><country name="Japon"><noRegion><name sortKey="Adachi, Chihaya" sort="Adachi, Chihaya" uniqKey="Adachi C" first="Chihaya" last="Adachi">Chihaya Adachi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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